Bromination of Acetanilide

The objective of this experiment was to use melting point and NMR to determine which of two isomers, ortho or para, would most likely form after brominating Acetanilide through electrophilic aromatic substitution. Procedure/Observations: 1. Weigh out ~280 mg of acetanilide in a 10 mL r. b. flask with a stir bar. 2. Then, add 2. 0 mL of glacial acetic acid using a calibrated Pasteur pipet. 3. Stir the mixture until all of the acetanilide has dissolved. It may be necessary to add more acetic acid dropwise until full dissolution has occured. In the fume hood, add 0. 6 mL of 4. 1 M bromine solution in acetic acid. 5. Cap the round bottom flask before returning to the bench. 6. For 15-20 minutes, stir the reaction mixture at room temperature so that the reddish-orange coloration will fade and a solid precipitate will form. 7. Return to the hood and add a few more drops of the bromine solution in the hood if all the coloration fades. 8. Once the reaction is complete, return to the hood. 9. Transfer the mixture to a 25 mL Erlenmeyer flask with 10 mL of water. 10. Rinse the reaction flask out using another 5. 0 mL of water. 11. Using a Pasteur pipet, add 30% sodium thiosulfate dropwise while swirling until the bromine coloration is no longer visible. 12. Return to the bench to complete the final work-up. 13. Cool the reacting mixture in an ice bath. 14. Collect the solid precipitate using a Hirsch funnel through vacuum filtration. 15. Wash with ice cold water to complete the transfer. If the crude product is yellow, disconnect the vacuum, add a few drops of the sodium thiosulfate solution, then reconnect the vacuum. Follow with 1 or 2 washings of ice cold water. 17. Dry the crude product 5-10 minutes using the vacuum. 18. Recrystallize the crude product using an ethanol/water mixed solvent combination. Be sure to dissolve the crude product in the minimal volume of hot ethanol with swirling. 19. Add water dropwise until a cloud point is reached. 20. Rewarm the solution until it is clear again. 21. Allow the solution to cool until crystals form before icing. 22. On a Hirsch funnel under vacuum using cold water washings collect the crystals. Continue the vacuum for 5-10 minutes to dry. 8. Find the final weight and calculate the yield. 9. Find the melting point of the product, then obtain the 1H NMR of the product in CDCl3. Overall Reaction: Mechanisms: Stoichiometric Table: CompoundMolar Mass (g/mol)Density (g/mL)mg or mLMmolMolar equiv. Acetanilide (Limiting Reagent)135. 171. 22333. 0 mg2. 46 1. 00 Bromine soln. 159. 803. 1190. 6 mL24. 610. 0 Glacial Acetic acid60. 051. 0492 mL34. 914. 2 Calculations 1) Moles of Acetanilide Used = 0. 333g/135. 17g/mol *1000 = 2.46mmol. Moles of Bromine Solution Used = 4. 1M * 0. 0006L = 24. 6mmol 3) Moles of Glacial Acetic Acid Used = 1. 049g/ml * 2. 00ml * 1mol/60. 05g/mol = 34. 9mmol 4) Molar equivalent of Bromine soln. = 24. 6 mmol / 2. 46mmol = 10. 0 5) Molar equivalent of Glacial Acetic Acid = 34. 9mmol / 2. 46mmol = 14. 2 6) Theoretical Yield of Product = 214. 07g/mol * 0. 00246mol = 0. 527g 7) Crude yield of product = 0. 1471g 8) Actual Yield of Product = 0. 0912g 9) Percent recovery from recrystallization = 0. 0912g/0. 1471g * 100 = 61. Percent yield = 0. 0912g/0. 527g * 100 = 17. 3% Results: Theoretical Yield of Product: 0. 527g Actual Yield of product: 0. 0912g Percent yield from recrystallization: 61. 9% Percent Yield of Product: 17. 3% Literature Melting Point Range: 166-170Â °C Experimental Melting Point Range: 165. 5-166. 5Â °C NMR Data: Shift (ppm)SignalIntegrationAssignment 7. 382-7. 434Multiplet 4 (2 for each aromatic proton-overlapping)Aromatic protons ortho and meta to the acetamido group 7. 260SingletProteolated SolventCDCl? impurities 2. 168Singlet3Methyl group

Language of Thought and Fodor Essay Example | Topics and Well Written Essays - 2500 words

Language of Thought and Fodor - Essay Example This paper is based on his book titled The Language of Thought, as it seeks to prove that Fodor was right in saying that the nature of human thought requires the existence of a language of thought that is not one's native language. At the very onset, it is imperative to highlight the main features of the nature of human thought. Human thought is that course or process which enables a human being to make rational choices and recognise symbols. This process goes beyond language, according to Fodor. It is contained in the laws of nature and the reaction that a human instinctively offers in the study of these laws. Here, it is imperative to speak about language so as to compare and contrast the two before proving Fodor's theory. (Fodor, 1975) The knowledge of a language is akin to the art of knowing about an entire culture, nation and people. Language may be defined as a form of expression that reveals a person's identity and gives him or her a sense of belonging. But how does a language structure a person's experiences To begin with, the role of language in one's life is one that fulfils the need to belong. This sense of belonging springs from one's immediate environment where there is focus on the language one speaks along with complementary elements like accent, nuances and other such features that form the general social and cultural terrain of the particular place. Language offers people first hand knowledge of a variety of symbols that one comes to associate with a place. This in turn generates a more enriching quality to one's experiences. (Mercer, 1996) In knowing and learning a language, whether by birth or subsequent settlement, there is a certain amount of satisfaction that helps contribute to one's sense of identity. This also has certain mental implications as it shows the person's basic aptitudes, besides brining him or her face to face with the challenges of implementing the language. This makes a person draw from experiences of the past, learn from present experiences and contribute to future experiences, which will shape his or her overall life experiences. This also renders a certain amount of creative and communicative competency to a person and his or her sense of confidence with which he or she carries out interactions with people. If Fodor is to be believed, then the competency of a person comes from being able to effectively use language to portray what is within. For this, it is imperative to portray the most elementary human thought in a language that transcends words, diction and pronunciation. This connects langua ge with experience. (Fodor, 1975) In this regard, it is necessary to shift focus to the process of learning of a language and garnering communicative competency. This process is important in every individual's life as the knowledge comes only after learning. The very process of learning is a journey throughout which an individual is brought face to face with experiences. These experiences form his or her general perspective on things. In this way, there is a certain level of competency which in turn, springs from the areas and experiences that a person finds comfortable to deal with. Learning a language is a crucial part of describing how a language shapes a person's experiences. (Girvin, 2000) Learning a language has always been a great challenge. While this is a matter of creating awareness, it is also a matter of creating certain comfort level that will trigger communicative com

Site Survey and Final Project Assignment Example | Topics and Well Written Essays - 2500 words

Site Survey and Final Project - Assignment Example As the building is so tall and the third largest insurance company in the US is located inside it, so it is always a responsibility of the security agents to run a periodic check. It is because large transactions are done and there is the need for protection of the company. The employees have a special batch which entitles them their identification and so they become distinguishable from the other visitors. There is also a strict rule that the employees should wear them. There are many special visitors to the place sometimes who are escorted by the guards and special honor is given to them. The building was built in 1993 at the expense of $100 million and was named as the capital holding center at first. The building is also constructed mainly of the reinforce concrete with full steel constructions as it is so tall. It has a dome at the top which is a distinguishing factor and it demarcates the name capital holding at night from the interiors of the building. The fences are given aro und it which is also very strong which is another factor of being distinguishable. There are many special features in the building like the half acre plaza which is made up of patterned granite and is decorated with lamps, flower trees and four fountains. It can be termed as a very famous architectural identification which is a good symbolization of the work of the people. The building has a five level garage to support the vehicles as they may be large in number. Polished black granite is also used which is very attractive. The full building is lighted which is also sufficient to detect people going at a reasonable distance. The color of the lighting has a fluctuation from white to reddish green from Thanksgiving Day to New Year. The lighting system has special security such that no one gets to the power system in the building responsible for lighting. There are special alarms in the building such that everything gets traced when there is an emergency relating to fire or any theft. The police and the fire departments are always kept in contact so that assistance can be taken. The alarms are so designed that they also do some additional functions like strengthening the security and sealing all important information along with notifying the people. There are cameras which keep an eye on the movements of the people and they are operated by special security professionals in the building. They also have the control over the cameras and that helps in the monitoring of the building continuously. There are some arrangements made such that the people don’t face any problem when there is an emergency. Special exit points are there and the building is given hidden support from inside to withstand such acts. There are systems such that both the people and the employees can get out of the building whenever there is an emergency and no one will be unsecured. After all the building is a great place which is the tallest and also maintained in a fashionable way. Facili ty characterization Physical conditions: The building is a great monument like structure which is surrounded by fences from all sides and has strong walls which make it safer. As it is an old building, there are every steps being taken towards its conservation. The building has a dome on the top which is a symbolism of the great art and architecture. The AEGON center has square feet of space and has a skyline silhouette so that it can be distinguished as the tallest building in Kentucky. Facility operations: The buildin